IQ Webinar: In Vitro to In Vivo Correlations of Transporter Based Drug-Drug Interactions
In Vitro to In Vivo Correlations of Transporter Based Drug-Drug Interactions: Learnings from IQ Transporter Working Group Data Collection Project
7 December 2023
11:00 AM – 12:00 PM ET
Presented by the Transporter Working Group
Sponsored by the Clinical Pharmacology and Translational and ADME Sciences Leadership Groups
- Daniel Bow, AbbVie
- Kathleen Hilgren, Eli Lilly
In order to improve the understanding and risk management of clinical transporter-mediated DDIs, the IQ Transporter Working Group completed an extensive data collection project of both in vitro (substrate liability and inhibition) and clinical transporter data (victim and perpetrator DDIs) on IQ member company drugs and new molecular entries. The primary goal of the project was to investigate the in vitro to in vivo correlation of transporter drug interactions for DDI and identify the overall interaction magnitude and clinical implications of the studies. In vitro substrate and inhibition data, including assay conditions, and clinical DDI study data was collected anonymously. The collection included compound characteristics such as physicochemical properties, general available ADME properties including permeability, protein binding, blood to plasma partitioning and PK parameters The demographic data and the in vitro to in vivo correlation of the data will be presented and compared with the current regulatory decision trees.
This webinar is open to the public. Membership in the IQ Consortium is not required for registration.