IQ Webinar: Approaches for Sensory Evaluation of Medicine Palatability
Speaker: Alexander Bachmanov, GlaxoSmithKline
Presented by the IQ Drug Product Leadership Group Pediatric Working Group
Many Active Pharmaceutical Ingredients have unpleasant (aversive) bitter taste, which can impede compliance with orally administered or inhaled formulations, especially in children. Ethical, legal and practical considerations limit use of humans for assessing palatability of drugs. Non-human approaches for sensory assessment help to predict palatability issues early in drug development, and to design mitigation strategies.
In this webinar, Dr. Abramov will review human and non-human approaches for evaluation of medicine palatability:
- Human sensory tests
- In vivo: e.g., rodent Brief Access Taste Aversion (BATA) tests
- In vitro: human taste cell cultures
- In vitro: heterologous expression of the human bitter (TAS2R) receptors in cell cultures
- In silico: docking of receptor-ligand interactions
- Biological sensors: Dictyostelium
- Electronic sensors: Electronic tongue
Discussion will include advantages and disadvantages of each approach, and their applicability for detecting and mitigating palatability issues.